Excipients for Drug Formulation

Disintegration for solid oral dosage forms – functional solutions from BASF

A disintegrant ensures that a solid oral dosage form quickly breaks into smaller fractions in order to ensure a fast release of the drug. BASF offers disintegrants across a broad range of particle sizes, making any type of desired formulation possible.

Disintegrants disperse a dosage form into smaller particles as soon as they reach an aqueous environment, i.e. through swelling. With this breakdown into smaller units, the medium is exposed to more of the active ingredient surface, which then dissolves to be adsorbed. Without the disintegrant, a significant amount of a drug could ultimately pass the body without ever getting to action.

BASF choice of disintegrants offers

  • highly efficient disintegration
  • the right particle for your size of dosage form

Disintegrants for your formulation need

BASF offers disintegrants with a variety of particle sizes. This choice allows the formulation of effectively disintegrating tablets from very small (i.e. hormone tablets) to large (i.e. supplements) With Kollidon® CL-F, we offer a mid-range particle size disintegrant that combines both strong disintegration functionality with desirable characteristics regarding organoleptics and storage behavior. In addition, we also offer disintegration solutions for orally disintegrating tablets (ODT) that require immediate disintegration in the saliva – including our ready and easy-to-use co-processed Ludiflash®.


Orally Disintegrating Tablets - enhancing ease of use and patient compliance

Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter medications. In contrast to classical tablets, ODTs are specifically designed to disintegrate directly in the patient's mouth. The disintegrated tablet can then be swallowed easily without any resistance. BASF offers a comprehensive set of excipients that help you to easily formulate your active ingredient in an effective ODT.

Solutions for ODT

Ludiflash® – The taste of success

Ludiflash® is an all-in-one solution: fillerbinder, and disintegrant that provides tablets with exceptional hardness and low friability, while giving your ODT an outstandingly creamy mouthfeel. It lowers storage and analytical costs and accelerates product development and process validation. Tableting is possible with any conventional equipment and any preferred packaging type. Ludiflash® enhances the cohesion with API‘s and is compatible with many typical ingredients in standard formulations.

Ludiflash® Product Page

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Our choice of functional disintegrants covers any size of dosage form you want to formulate.

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