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Excipients for Drug Formulation
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Excipients for Drug Formulation

Disintegration for solid oral dosage forms – functional solutions from BASF

A disintegrant ensures that a solid oral dosage form quickly breaks into smaller fractions in order to ensure a fast release of the drug. BASF offers disintegrants across a broad range of particle sizes, making any type of desired formulation possible.

Disintegrants disperse a dosage form into smaller particles as soon as they reach an aqueous environment, i.e. through swelling. With this breakdown into smaller units, the medium is exposed to more of the active ingredient surface, which then dissolves to be adsorbed. Without the disintegrant, a significant amount of a drug could ultimately pass the body without ever getting to action.

BASF choice of disintegrants offers

  • highly efficient disintegration
  • the right particle for your size of dosage form
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Disintegrants for your formulation need

BASF offers disintegrants with a variety of particle sizes. This choice allows the formulation of effectively disintegrating tablets from very small (i.e. hormone tablets) to large (i.e. supplements) With Kollidon® CL-F, we offer a mid-range particle size disintegrant that combines both strong disintegration functionality with desirable characteristics regarding organoleptics and storage behavior. In addition, we also offer disintegration solutions for orally disintegrating tablets (ODT) that require immediate disintegration in the saliva – including our ready and easy-to-use co-processed Ludiflash®.

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Orally Disintegrating Tablets - enhancing ease of use and patient compliance

Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter medications. In contrast to classical tablets, ODTs are specifically designed to disintegrate directly in the patient's mouth. The disintegrated tablet can then be swallowed easily without any resistance. BASF offers a comprehensive set of excipients that help you to easily formulate your active ingredient in an effective ODT.

Solutions for ODT
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Ludiflash® – The taste of success

Ludiflash® is an all-in-one solution: filler, binder, and disintegrant that provides tablets with exceptional hardness and low friability, while giving your ODT an outstandingly creamy mouthfeel. It lowers storage and analytical costs and accelerates product development and process validation. Tableting is possible with any conventional equipment and any preferred packaging type. Ludiflash® enhances the cohesion with API‘s and is compatible with many typical ingredients in standard formulations.

Ludiflash® Product Page

Learn more about our solutions for disintegration

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BASF Pharma solutions for Orally Disintegrating Tablets

American Pharmaceutical Review

A recent advancement in orally disintegrating formulations

Portfolio Overview

Focusing on your needs with platform solutions

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Download Center

Looking for application guides, technical and scientific posters, brochures or technical information? Visit our Download Center.
Disintegrants Download Center

Our choice of functional disintegrants covers any size of dosage form you want to formulate.

Kollidon® CL

The Kollidon® CL family is the industry’s widest portfolio of super-disintegrants and dissolution enhancers. These highly functional cross-linked PVP polymers ensure that active ingredients are released from any solid dosage form at exceptionally high speed. In addition, they improve bioavailability of certain poorly soluble APIs.

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Kollidon® CL-F

Due to the balance of strong disintegration and optimal surface homogeneity our crosspovidone Kollidon® CL-F is your first choice tablet disintegrant. The super-disintegrant is specifically suitable for use in small tablets to fasten disintegration and dissolution. Kollidon® CL-F can also be used in wet granulation processes, when large amount of granulation liquids are needed.

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Kollidon® CL-M

Kollidon® CL-M is used as a stabilizer for oral and topical suspensions and to improve the drug release characteristics of tablets, capsules or granules. Our disintegrant with micronized particles, delivers a slight disintegration functionality when used as binder. The crosspovidone is also used as pore former in some formulations.

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Kollidon® CL-SF

The finest grade of water-insoluble crospovidone disintegrant available in the market for small and orally disintegrating tablets. It provides smooth tablet surface and cream-like mouth feel. Kollidon® CL-SF strongly improves tablet hardness and has a strong ability to absorb water.

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Ludiflash® – The taste of success

Ludiflash® is an all-in-one solution: filler, binder, and disintegrant that provides tablets with exceptional hardness and low friabilit, while giving your ODT an outstandingly creamy mouthfeel. It lowers storage and analytical costs and accelerates product development and process validation. Tableting is possible with any conventional equipment and any preferred packaging type. Ludiflash® enhances the cohesion with API‘s and is compatible with many typical ingredients in standard formulations.

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Processes related to binding

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Direct Compression

Direct compression (DC) is the most economic way to produce a tablet as it is the shortest and most direct way to get from powder mix to final dosage form. BASF offers all functional excipients to successfully develop a DC process for your drug, including key elements like appropriate binder and lubricant.

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Dry Granulation

Dry granulation is a great choice to produce solid oral dosage forms if cost and process efficiency are essiential. BASF offers the most effective dry binders available, along with all other functional materials and expertise required to help you develop your process successfully.

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Wet Granulation

BASF offers the key functional materials required to achieve great wet granulation results.

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