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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Enteric release

Instant & Modified Release

Global
Excipients for Drug Formulation

Functional solutions for formulations with enteric drug release

When the active ingredient is not supposed to be released in the stomach, a formulator will design his dosage form with an enteric release profile. BASFs enteric release excipients offer maximum functionality while being the most easy-to-apply.

With an enteric release profile, the drug release of the drug is delayed until the dosage form reaches the intestine. This release characteristic is typically chosen either to protect the stomach from a drug (i.e. acetylsalicylic acid), or to protect a sensitive drug from the acids in the stomach (i.e. most proton pump inhibitors). Enteric release profiles are also used for omega-3 softgel capsules in order to prevent dissolution of the capsules in the stomach, potentially leading to unpleasant burps. And in combination with effective sustained release excipients like Kollicoat® SR 30 D, enteric release polymers can also be used for delayed sustained drug release starting only in the intestine. BASF offers the most widely used functional excipient for enteric release profiles in both aqueous and powderous form. Either one of them offers simple processing and reliable functional results.

BASF materials for enteric release offer all that you expect from a functional excipient

  • Fully reliable functional performance for a maximum of patient security and compliance
  • High functional efficiency –
    achieving the desired release effect already at low use
  • Easy
    processing

Discover more about enteric release solutions

Product One Pager

Kollicoat® MAE 100-55: A complete match – just better.

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Product innovation on modified release coatings (sustained release and enteric coatings)

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Overcoming Softgel Coating Challenges

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Our range of products for the enteric release profile of your dosage form

Kollicoat® MAE 100-55

A complete match – just better. Kollicoat® MAE 100-55 combines two things hard to bring together – it can directly exchange the comparable pH 5.5 enteric release coating polymer in your commercial formulations, and still bring signifi cant handling improvement to your operators because it does not dust at all.

Kollicoat® MAE 100 P

Enteric coating with release above pH 5.5, coming as partially pre-neutralized powder saving you the neutralization step.

Kollicoat® MAE 30 DP

Enteric coating with release above pH 5.5, coming as a 30 % solids content dispersion.

Approaches for the design of sustained drug release

Coating / Layering

Solid oral dosage forms are coated to apply a range of functions: from attractive colored instant-release coatings or robust taste-masking to functional coatings defining enteric or sustained release. BASF offers all major coating types plus as well as plasticizers for your successful coating formulation.

Film Forming

In formulation processes film formers provide a range of functionalities via a coating layer. BASF offers a full range of highly efficient film formers for all dosage forms.

Matrices & Fillers

BASF offer specific highly functional matrix formers as well as a selection of ready-to-use tablet and ODT bases that include filler and all other necessary components.

Pore Forming

BASF offers a whole range of pore formers that can be used to tune sustained drug release in almost endless ways.

Softgel Coatings

Customized solutions for the effective coatings of softgels to provide enteric sustained release and moisture protection.

Taste Masking

Whether you are looking for taste masking in a solid or a liquid dosage form, BASF has a whole range of solutions at hand.