Excipients for Drug Formulation

Moisture Protection

Moisture protection is typically applied to protect a sensitive active ingredient from degradation and/or to avoid the dosage form from deformation and poor performance. BASF offers moisture protective coatings which secure active ingredients from environmental moisture throughout its lifetime.

Moisture protection for solid oral dosage forms has become a regular requirement in the pharmaceutical industry. One driver is that a range of active ingredients is sensitive to moisture-related degradation. Another trend that significantly contributes to the increase in importance of moisture protection is the continuous growth of pharmaceuticals in emerging markets. There, high humidity combined with non-blister packaging or even sale of single doses creates immediate need to make sure that single doses remain unaffected, both in terms of efficacy as well as visual and haptical appearance.

Protect your active ingredient from moisture

  • Avoidance of API degradation
  • Reduced risk of failure in dosage form appearance
  • Increased flexibility in packaging
  • BASF polymers for robust production processes and consistently good results

BASF offers polymer solutions specifically designed for moisture protection. Our Kollicoat® Protect is the rock-solid, Kollicoat® IR-based moisture protection that is highly effective in combination with pigments – and its performance can even be improved when Kollidon® VA 64 is added to the film formulation.

Kollicoat® Smartseal 30 D is the high-end choice for the toughest challenges. So if your drug is extra sensitive or even hygroscopic, or if you only have room for a very thin layer of film coating – then Kollicoat® Smartseal 30 D is your choice. It is effectively keeping moisture out already at very low coating levels.

Kollicoat® Smartseal 30 D
Highly efficient sealing against moisture

Breaking new ground in taste masking and moisture protection: Kollicoat® Smartseal 30 D is the first waterbased polymer dispersion for taste masking and moisture barrier applications.

Film coatings with a low water vapor permeability can delay the moisture uptake of sensitive cores. Tests on isolated films show that Kollicoat® Smartseal 30 D has a lower water vapor permeability than other leading protective coatings.

Kollicoat® Smartseal 30 D was developed to simplify and accelerate aqueous film coating operations, and opens new doors for formulating tablet, pellet, particle and softgel coatings.

Kollicoat® Smartseal 30 D (Product Website)

The first waterbased polymer dispersion for taste masking and moisture barrier applications: Kollicoat® Smartseal 30 D

Discover more about our moisture protection solutions

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Moisture protection solutions from BASF

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