Pore formers are typically used to create a certain amount of diffusion through an insoluble coating of a tablet, pellet or particle to achieve a sustained release profile. BASF offers a whole range of pore formers that can be used to tune sustained drug release in almost endless ways.
When a sustained drug release profile is developed, a common way to achieve it is the combination of an insoluble coating (i.e. made from Kollicoat® SR 30 D) with a soluble pore former. While the coat itself will remain intact throughout its passage, the pore former will dissolve at the targetet point in the body, allowing the active ingredient in the core to diffuse out of the dosage form. In this context, there are key parameters relevant to design the release profile to the exact need:
It represents a particular challenge to formulate hydrophilic drugs in a sustained release dosage form. Here we offer intelligent formulation solutions based on liphophilic pore formers like Kolliwax® HCO, or by applying well-known physiochemical concepts like thermal sintering, to establish sustained release using a combination of Kollicoat® SR 30 D and Kolliwax® S Fine.
Discover more about pore forming solutions from BASF