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Excipients for Drug Formulation

Sustained release

Global
Excipients for Drug Formulation

Functional solutions for formulations with sustained drug release

Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.

One of the major challenges for marketers of pharmaceutical products is the compliance of the patient. When a drug needs to be adminstered several times a day, patients acceptance of the medication can decrease considerably, leaving the risk of insufficient treatment. A common solution to increase medication acceptance in this case is to formulate the drug in a dosage form that releases the active ingredient steadily over an extended period of time. Such sustained release formulations have gained considerable traction in the pharmaceutical industry, and will continue to be a major tool to improve the patients experience for existing and new drugs. It also represents an attractive opportunity for companies and formulators in particular to differentiate their potentially generic product from standard instant release versions in the market. We offer a distinct set of highly functional materials that allow you to flexibly design your desired sustained release profiles.

Sustained release solutions

  • Increased patient compliance
  • Differentation of your dosage form in the market

  • Efficient processing, reducing ecological footprint

Sustained release formulations meeting the ADD regulations

Modified release dosage forms are helpful for patients, as they provide pharmacological advantages and administration convenience. However, dose dumping, which is defined as the rapid release of a large portion or the entire dose, is of growing concern. This is often the consequence of the consumption of alcoholic beverages (so-called alcohol induced dose dumping, ADD). This is of particular concern as it may unintentional put the patient at significant health risks. Regulatory bodies worldwide have lately adapted regulations in order to avoid the risk of such accidental dose dumping.

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Our range of products that can be used to design sustained release profiles for your dosage form

Approaches for the design of sustained drug release