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Excipients for Drug Formulation
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Excipients for Drug Formulation

Sustained release

Global
Excipients for Drug Formulation

Functional solutions for formulations with sustained drug release

Sustained release profiles allow tailored dosing of the active ingredient over an extended period of time up to 24 hours. Common ways to achieve such release rates are the use of film coating, a sustained release matrix or sustained release drug-loaded granules. BASF offers powerful excipients that provide almost endless design space for sustained release formulations.

One of the major challenges for marketers of pharmaceutical products is the compliance of the patient. When a drug needs to be adminstered several times a day, patients acceptance of the medication can decrease considerably, leaving the risk of insufficient treatment. A common solution to increase medication acceptance in this case is to formulate the drug in a dosage form that releases the active ingredient steadily over an extended period of time. Such sustained release formulations have gained considerable traction in the pharmaceutical industry, and will continue to be a major tool to improve the patients experience for existing and new drugs. It also represents an attractive opportunity for companies and formulators in particular to differentiate their potentially generic product from standard instant release versions in the market. We offer a distinct set of highly functional materials that allow you to flexibly design your desired sustained release profiles.

Sustained release solutions

  • Increased patient compliance

  • Differentation of your dosage form in the market

  • Efficient processing, reducing ecological footprint

Sustained release formulations meeting the ADD regulations

Modified release dosage forms are helpful for patients, as they provide pharmacological advantages and administration convenience. However, dose dumping, which is defined as the rapid release of a large portion or the entire dose, is of growing concern. This is often the consequence of the consumption of alcoholic beverages (so-called alcohol induced dose dumping, ADD). This is of particular concern as it may unintentional put the patient at significant health risks. Regulatory bodies worldwide have lately adapted regulations in order to avoid the risk of such accidental dose dumping.

Learn more with our webinars, articles and posters

ebook

Overcoming Challenges in Sustained-Release Drug Formulation

Webinar (on demand)

Product innovation on modified release coatings (sustained release and enteric coatings)

Webinar (on demand)

Sustained-Release Formulation: Overcoming Key Challenges Like Alcohol-Induced Dose Dumping

Webinar (on demand)

Thermal Sintering for  Controlled Drug Release of Hydrophilic Drugs

Learning Tool

Overcoming Challenges in Sustained-Release Drug Formulation

American Pharmaceutical Review

Controlled release: a new paradigm with polyvinyl acetate polymer

Portfolio Overview

Focusing on your needs with platform solutions

Download Center

Looking for application guides, technical and scientific posters, brochures or technical Information? Visit our Download Center.

Our range of products that can be used to design sustained release profiles for your dosage form

Kollicoat® SR 30 D

Precise, pH-independent sustained release for multiple applications

Kollidon® SR

Direct Compression Sustained Release

Kolliwax® HCO

Kolliwax® HCO is hydrogenated castor powder for pharmaceutical application used as consistency factor in topical formulations, as lipohphillic lubricant in tablets and capsules and as plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. Kolliwax® HCO is particularily suitable for formulation of sensitive APIs.

Kolliwax® SA Fine

As lipophilic lubricant Kolliwax® SA Fine is the first choice for sensitive acidic APIs. It is used as lubricant and matrix former. It hardens suppository formulations and adjust their melting points.

Kolliwax® S Fine

Kolliwax® S Fine can be used for various oral solid as well as semi-solid dosage forms: It can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories. Kolliwax® S Fine is particularly suitable for sensitive APIs.

Approaches for the design of sustained drug release

Binding

BASF offers the most comprehensive range of binders for any formulator challenge – from formulating highly sensitive drugs to establishing efficient continuous processing.

Coating / Layering

Solid oral dosage forms are coated to apply a range of functions: from attractive colored instant-release coatings or robust taste-masking to functional coatings defining enteric or sustained release. BASF offers all major coating types plus as well as plasticizers for your successful coating formulation.

Matrices & Fillers

BASF offer specific highly functional matrix formers as well as a selection of ready-to-use tablet and ODT bases that include filler and all other necessary components.

Pore Forming

BASF offers a whole range of pore formers that can be used to tune sustained drug release in almost endless ways.