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Excipients for Drug Formulation
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Excipients for Drug Formulation
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Excipients for Drug Formulation

Functional solutions for
your softgel formulation

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Excipients for Drug Formulation

Softgel Fills – Find the right fill for your Softgel formulation needs

At BASF we offer a comprehensive range of high quality functional excipients, vitamins and omega-3 fish oils to support you in finding the right capsule fill for your formulation needs. This unique combination of products builds a bridge between dietary supplements and pharmaceutical products.

Benefits

  • Leading in softgel fills with a broad portfolio from Omega-3, to Vitamins and functional excipients
  • Extensive expertise in softgel technology through Omega-3 Verbund
  • Unique combination of products building a bridge between dietary supplements and pharmaceutical products
  • Extensive expertise in oleochemicals and polymer chemistry
  • Hydrophilic fills of the highest purity to minimize gelatin crosslinking and API reactions

Solvents and Fills

From dietary supplements to complex self-emulsifying drug delivery systems for the formulation of poorly soluble APs. At BASF we offer a comprehensive range of high quality functional excipients, vitamins and omega-3 fish oils to support you in finding the right capsule fill for your formulation needs. This unique combination of products builds a bridge between dietary supplements and pharmaceutical products. Furthermore, all ingredients have been tested according to the highest quality standards to minimize the possibility of crosslinking.

Omega-3 - expertise in softgel formulations

BASF is the pioneer in omega-3, with its foundations in Norway in 1838. We are world leader in high-concentrate omega-3 fatty acids for pharmaceuticals, dietary supplements and clinical nutrition categories. Our leadership is built on a global customer reach, R&D capabilities for lipids, omega-3 derivates and development of omega-3 fatty acid formulations, and an unrivalled worldwide safety and efficacy data on omega-3 softgel drugs such as Omacor®, Lovaza™, Lotriga®, Zodin®.

Omega 3

- Extensive expertise in softgel technology through Omega 3 Verbund
- Hydrophilic fills of the highest purity to minimize gelatin crosslinking and API reactions
- Compliance with all regulatory requirements
- Pioneering in Omega 3 since 1838

Solubilization enhancement and emulsification

More and more drugs in development exhibit low solubility. Therefore, poorly soluble drugs are one of the major challenges pharmaceutical manufacturers are facing. Self-emulsifying drug delivery is one option enhance solubility and bioavailability for lipophilic drug. BASF offers a comprehensive range of high quality solubilizers, lipids and solvents for this challenge. Finding the right combination of emulsifier, co-emulsifier and solvent for a self-emulsifying drug delivery system has been traditionally a trial and error approach; BASF can offer high throughput screening tools in order to speed up formulation time.

Crystallization inhibition for enhanced bioavailability

Crystallization inhibition is an important factor to maintain drug solubility and bioavailability out of solid and liquid dosage forms in particular. Before it can be adsorbed, recrystallization can happen at any point in time after formulation, during storage or administration, causing bioavailability to plummet and a consequent loss of medication efficacy. BASF offers a range of well established crystallization inhibitors that ensure that your drug will not get lost on its way to the point of action in the body, i.e. our low molecular weight povidones Kollidon® 12 PF and Kollidon® 17 PF or our Kollicoat® MAE 100-55.

Discover more about fill solutions for your softgel formulation

Portfolio Overview

Focusing on your needs with platform solutions

Webinar (on demand)

Practical Considerations for Overcoming Bioavailability Challenges with LBDDS

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The Formulation Complex: Unravelling the challenges and trends in formulation best practice – and why lipids and softgels are leading the way.

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Current Solubilization Techniques: Insights from the BASF Solubilization Symposium

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Formulation Technologies and Excipient Selection: Strategies for Improving Solubility

The Medicine Maker

From Brick Dust to Blockbuster? - Self-emulsifying lipids, and other innovative solubilizers and polymers

Download Center

Looking for application guides, technical and scientific posters, brochures or technical information? Visit our Download Center.

Fills for your softgel

APIs for Softgels

BASF's offers a range of active pharmaceutical ingredients (APIs) suitable for softgel applications.

Crystallization Inhibitors

BASF offers a range of well established crystallization inhibitors that ensure that your drug will not get lost on its way to the point of action in the body.

Hydrophilic Fills

Due to our unique manufacturing process, BASF offers products that conform to highest quality standards in the industry.

Lipophilic Fills

Highly functional lipophilic fills and surfactants to be used in multitude of softgel applications including self-emulsifying systems, suspensions and solutions.

Solubilization Enhancement

BASF offers a comprehensive range of high quality lipids, solvents and solubilizers to enhance solubiliuty and bioavailability of poorly soluble drugs in softgel formulations.

Discover our portfolio of your softgel fill needs

Kollidon® 12 PF

Low-molecular grade Kollidon®, intended for use as solubilizing agent, dispersant and crystallization inhibitor particularly for injectables. In addition applicable as pore former in solid dosage forms and viscosity enhancer in parenterals.

Kollidon® 17 PF

Low-molecular grade Kollidon®, intended for use as solubilizing agent, dispersant and crystallization inhibitor, particularly for injectables. In addition applicable as pore former in solid dosage forms and viscosity enhancer in parenterals.

Kollidon® 30

Our medium-molecular povidone is used in endless ways in pharmaceutical formulations - as binder, pore former, stabilizer, thickener, as solubilizing agent, crystallization inhibitor and many more. And with our trusted quality, it will always serve exactly what you intended it for.

Kollidon® 90 F

A highly effective binder, for use as a stabilizer in oral and topical suspensions, as a thickener, and as a hydrophilizing agent or pore-forming agent in medical plastics.

Kollidon® VA64

Kollidon® VA64 is used in granulation and as a dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Soluble copovidone widely used for instant release formulation and is suitable in hot-melt extrusion processes.

Kolliphor® CS 12

A non-ionic emulsifier; stable with acidic, basic and ionic excipients.

Kolliphor® CS 20

A non-ionic emulsifier with good sensory properties; stable with acidic, basic and ionic excipients.

Kolliphor® EL

BASF's non-ionic solubilizer and emulsifier for the production of semi-solid and liquid formulations of water-insoluble actives and other hydrophobic compounds.

Kolliphor® ELP

Kolliphor® ELP is a non-ionic oil-in-water emulsifier and/or solubilizer for sensitive active ingredients

Kolliphor® HS 15

A potent nonionic solubilizer

Kolliphor® P188

Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with increased efficiency and added functionality.

Kolliphor® P 338

A polymeric multi-talent suitable for a large variety of applications, i.e. Kolliphor® P 338 can be used as solubilizer, emulsifier and plasticizer.

Kolliphor® P 407

A polymeric multi-talent suitable for a large variety of applications, i.e. as thickening agent and gel former and as a co-emulsifier and viscosity enhancer in creams and liquid emulsions.

Kolliphor® PS 20

Kolliphor® PS 20 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like emulsions and creams, gels and foams as well as softgels.

Kolliphor® PS 60

Kolliphor® PS 60 is used as an emulsifier or co-emulsifier in topical pharmaceutical applications like creams and lotions and as non-ionic solubilizer in solid, semi-solid and liquid dosage forms or as foam stabilizer.

Kolliphor® PS 80

Kolliphor® PS 80 is a non-ionic, hydrophilic emulsifier, co-emulsifier and solubilizer for pharmaceutical preparations like like emulsions and creams, gels and foams as well as softgels.

Kolliphor® RH40

Non-ionic oil-in-water solubilizer and emulsifying agent

Kollisolv® MCT 70

Medium chain triglyceride compatible with fat-soluble vitamins, actives and essential oils

Kollisolv® P 124

The only monographed poloxamer that is liquid at room temperature – making it ideal for liquid dosage forms. It is used for liquid-filled softgel capsules as a dispersion medium for APIs, or as plasticizer for tablet formulations.

Kollisolv® PEG 300

Excellent solvents for a large number of substances that do not readily dissolve in water

Kollisolv® PEG 400

Excellent solvents for a large number of substances that do not readily dissolve in water

Kollisolv® PG

Manufactured under cGMP, Kollisolv® PG (1,2-propyleneglycol) can used across a wide range of applications, i.e. as plasticizer, solvent or co-solvent, stabilizer, or as carrier for emulsifiers.

Kolliwax® CSA 50

A fatty alcohol mixture, preferred for its stability in emulsion formulations.

Kolliwax® GMS II

A solvent for oral, topical applications, co-emulsifier and low HLB surfactant, structure-building consistency factor for semi-solids and a viscosity enhancer. It also hardens suppository formulations and adjust their melting points.

Kolliwax® HCO

Kolliwax® HCO is hydrogenated castor powder for pharmaceutical application used as consistency factor in topical formulations, as lipohphillic lubricant in tablets and capsules and as plasticizer in solid dispersions using spray drying, melt granulation or hot melt extrusion processes. Kolliwax® HCO is particularily suitable for formulation of sensitive APIs.

Kolliwax® S

Kolliwax® S can be used for various oral solid as well as semi-solid dosage forms. Kolliwax® S can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories.

Novata®

The best option for suppository masses or solid compositions.

Related Solution Platforms

Solubilization Platform

Effective solubilization in solid & liquid dosage forms.

Softgels Platform

Functional solutions for all soft gel parts – fill, shell and coating.