Solubilization of poorly soluble active ingredients
Effective solubilization in solid & liquid dosage forms. The right path for greater solubility and bioavailability.
Poorly soluble drugs are one of the major challenges pharmaceutical manufacturers are facing. More and more drugs in development exhibit low solubility. At BASF, we offer a comprehensive range of cutting-edge solubilization polymers, and have an unparalleled understanding of the corresponding process technologies. This unique combination means that we can make sure you achieve effective solubilization across a range of dosage forms – particularly in solid dispersions.
Furthermore, BASF is a highly successful pioneer in the application of hot-melt extrusion technology in pharmaceutical production, which helps you combine effectiveness with cost efficiency.
Selecting the right solubilization product and technology for a poorly soluble API often involves a lot of trial and error. But partnering with our experts, you can tap into their extensive solubilization expertise and experience with all key technologies, such as hot-melt extrusion, spray drying, and drug layering. Our experts have access to industry-leading tools such as our high-throughput screening (HTS) robot. This puts them in an excellent position to help customers tackle their solubilization and bioavailability challenges rapidly and efficiently.
Choose Your Drug Delivery System
Solid dispersions – a great way to increase the solubility and bioavailability of your drug
Learn more about our solubilization solutions
Unlock the full potential of poorly soluble drug using ready-to-use SEDDS compositions & Introducing superSNEDDS – as way of increasing the applicability of lipid-based drug delivery systems
Discovery, Formulation, and Performance of Self-Emulsifying Drug Delivery Systems (SEDDS)
Formulation Technologies and Excipient Selection: Strategies for Improving Solubility
The Science of Insolubility: Experts come together to discuss the chemistry of solubility – and the solutions of the future
The Formulation Complex: Unravelling the challenges and trends in formulation best practice – and why lipids and softgels are leading the way.
Practical Considerations for Overcoming Bioavailability Challenges with LBDDS ...
Choosing the Proper Dissolution Method When Testing Solubilization Performance
Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs
Twin Screw Wet Granulation for Solubility Enhancement of Poorly Water-Soluble Drugs
How glass-forming polymers improve bioavailability / Enhanced oral bioavailability with Soluplus® – case study
From Brick Dust to Blockbuster? - Self-emulsifying lipids, and other innovative solubilizers and polymers
SPECIAL FEATURE - Improving Bioavailability & Solubility: A Top-Down Versus Bottom-Up Approach
Micro-scale prediction method for API-solubility in polymeric matrices
The advantages and disadvantages of hot-melt extrusion in solid dispersion formulations
EXCIPIENT UPDATE - Soluplus®: An Understanding of Supersaturation From Amorphous Solid Dispersions