Solubilization of poorly soluble active ingredients
Effective solubilization in solid & liquid dosage forms. The right path for greater solubility and bioavailability.
Poorly soluble drugs are one of the major challenges pharmaceutical manufacturers are facing. More and more drugs in development exhibit low solubility. At BASF, we offer a comprehensive range of cutting-edge solubilization polymers, and have an unparalleled understanding of the corresponding process technologies. This unique combination means that we can make sure you achieve effective solubilization across a range of dosage forms – particularly in solid dispersions.
Furthermore, BASF is a highly successful pioneer in the application of hot-melt extrusion technology in pharmaceutical production, which helps you combine effectiveness with cost efficiency.
Finding the best solubilization solution
Selecting the right solubilization product and technology for a poorly soluble API often involves a lot of trial and error. But partnering with our experts, you can tap into their extensive solubilization expertise and experience with all key technologies, such as hot-melt extrusion, spray drying, and drug layering. Our experts have access to industry-leading tools such as our high-throughput screening (HTS) robot. This puts them in an excellent position to help customers tackle their solubilization and bioavailability challenges rapidly and efficiently.
BASF delivers answers to even the toughest solubilization challenges
- Comprehensive functional portfolio for solubiliation in solid & liquid dosage forms
- Innovative excipients for poorly soluble APIs
- Proven performance and safety
- Technology leader for key technologies such as hot-melt extrusion
- High throughput screening service Solu-HTS
Choose Your Drug Delivery System
Discover our solubilization solutions
Solubilization challenges need new ways
Role of Excipients in Amorphous Solid Dispersions
Drug Development Challenges
Innovation in Solubilization: Quo vadis?
Excipients and Solubilization
Choosing the right Solubilization Technology
The need for novel surfactants
Excipients selection for amorphous solid dispersions
API Supersaturation and Bioavailability Enhancement
Impact of Matrix Polymers
Opportunities for early-stage drug development
Testing the Functionality of Solubility Approach
What causes drug precipitation?
Lipid-Based Drug Delivery Systems
The importance of the structure activity relationship
Preparation Method and Amorphous Systems
In Conversation with Andreas Gryczke of BASF
Amorphous versus Co-Amorphous Systems
Using Lipid-Based Systems to Improve Solubility
Testing Lipid-Based Drug Delivery Systems Performance
Optimizing Lipid-based Drug Delivery Systems
How to keep your API in supersaturation?
Drug Delivery from Multiphase Systems
Biorelevant Dissolution Tests
Overcoming Solubility Challenges
Common Formulation Challenges
Nano-FTIR as characterization tool for ASD
Stabilizing Amorphous Drugs
Learn more about our solubilization solutions